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. 2011 Dec;34(6 Pt 2):e594-600.
doi: 10.1111/j.1365-2605.2011.01193.x. Epub 2011 Jun 15.

Magnesium and Anabolic Hormones in Older Men

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Free PMC article

Magnesium and Anabolic Hormones in Older Men

M Maggio et al. Int J Androl. .
Free PMC article

Abstract

Optimal nutritional and hormonal statuses are determinants of successful ageing. The age associated decline in anabolic hormones such as testosterone and insulin-like growth factor 1 (IGF-1) is a strong predictor of metabolic syndrome, diabetes and mortality in older men. Studies have shown that magnesium intake affects the secretion of total IGF-1 and increase testosterone bioactivity. This observation suggests that magnesium can be a modulator of the anabolic/catabolic equilibrium disrupted in the elderly people. However, the relationship between magnesium and anabolic hormones in men has not been investigated. We evaluated 399 ≥65-year-old men of CHIANTI in a study population representative of two municipalities of Tuscany (Italy) with complete data on testosterone, total IGF-1, sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEAS) and serum magnesium levels. Linear regression models were used to test the relationship between magnesium and testosterone and IGF-1. Mean age of the population was 74.18 ± 6.43 (years ± SD, age range 65.2-92.4). After adjusting for age, magnesium was positively associated with total testosterone (β ± SE, 34.9 ± 10.3; p = 0.001) and with total IGF-1 (β ± SE, 15.9 ± 4.8; p = 0.001). After further adjustment for body mass index (BMI), log (IL-6), log (DHEAS), log (SHBG), log (insulin), total IGF-1, grip strength, Parkinson's disease and chronic heart failure, the relationship between magnesium and total testosterone remained strong and highly significant (β ± SE, 48.72 ± 12.61; p = 0.001). In the multivariate analysis adjusted for age, BMI, log (IL-6), liver function, energy intake, log (insulin), log (DHEAS), selenium, magnesium levels were also still significantly associated with IGF-1 (β ± SE, 16.43 ± 4.90; p = 0.001) and remained significant after adjusting for total testosterone (β ± SE, 14.4 ± 4.9; p = 0.01). In a cohort of older men, magnesium levels are strongly and independently associated with the anabolic hormones testosterone and IGF-1.

Conflict of interest statement

Disclosures

None of the sponsoring institutions interfered with the collection, analysis, presentation or interpretation of the data reported here. None of the authors declared a conflict of interest.

Figures

Figure 1
Figure 1
Relationship between total testosterone and serum magnesium levels adjusted for age. The beta coefficient ± SE (β ± SE) of the age-adjusted analysis was 34.9 ± 10.3 with p-value = 0.0001.
Figure 2
Figure 2
Relationship between total growth factor 1 levels and magnesium levels adjusted for age. The beta coefficient ± SE (β ± SE) of the age-adjusted analysis was 15.9 ± 4.8 with p-value = 0.001.

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