Myricetin Induces Pancreatic Cancer Cell Death via the Induction of Apoptosis and Inhibition of the Phosphatidylinositol 3-kinase (PI3K) Signaling Pathway

Cancer Lett. 2011 Sep 28;308(2):181-8. doi: 10.1016/j.canlet.2011.05.002. Epub 2011 Jun 14.

Abstract

Pancreatic cancer is the fourth leading cause of cancer related deaths and is a disease with poor prognosis. It is refractory to standard chemotherapeutic drugs or to novel treatment modalities, making it imperative to find new treatments. In this study, using both primary and metastatic pancreatic cancer cell lines, we have demonstrated that the flavonoid myricetin induced pancreatic cancer cell death in vitro via apoptosis, and caused a decrease in PI3 kinase activity. In vivo, treatment of orthotopic pancreatic tumors with myricetin resulted in tumor regression and decreased metastatic spread. Importantly, myricetin was non-toxic, both in vitro and in vivo, underscoring its use as a therapeutic agent against pancreatic cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Cell Line, Tumor
  • Cell Survival
  • Disease Models, Animal
  • Flavonoids / pharmacology*
  • Humans
  • Immunohistochemistry
  • Mice
  • Mice, Nude
  • Pancreatic Neoplasms / pathology
  • Phosphoinositide-3 Kinase Inhibitors*
  • Signal Transduction / drug effects*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Flavonoids
  • Phosphoinositide-3 Kinase Inhibitors
  • myricetin