Nonsteroidal anti-inflammatory drugs-induced generalized fixed drug eruption: two cases

Hum Exp Toxicol. 2012 Feb;31(2):197-200. doi: 10.1177/0960327111412804. Epub 2011 Jun 15.


Fixed drug eruption (FDE) is a drug-induced cutaneous reaction that occurs at the same site with each exposure to a specific medication and usually manifests as round or oval, sharply demarcated erythematous or edematous plaques. The exact mechanism is unknown. The most common causative agent is co-trimoxazole. Other major categories of causative agents of FDE include antibiotics, antiepileptics, and nonsteroidal anti-inflammatory drugs (NSAIDs). FDE usually causes localized eruptions and very rarely generalized lesions. We report two cases of developing generalized FDEs after exposure to diclofenac and naproxen.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Diclofenac / adverse effects*
  • Drug Eruptions / etiology*
  • Drug Eruptions / pathology
  • Humans
  • Male
  • Middle Aged
  • Naproxen / adverse effects*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Diclofenac
  • Naproxen