Mitochondrial DNA lineages of African origin confer susceptibility to primary open-angle glaucoma in Saudi patients

Mol Vis. 2011;17:1468-72. Epub 2011 Jun 3.

Abstract

Purpose: We previously reported that certain mitochondrial DNA (mtDNA) polymorphisms in the coding region may be involved in the pathogenesis for primary open-angle-glaucoma (POAG). This encouraged us to extend our work and assess whether mtDNA diagnostic polymorphisms, defining geographically structured haplogroups, could be associated with the development of POAG.

Methods: We sequenced the mtDNA regulatory hypervariable region-I (HVS-I) region and coding regions, comprising haplogroup diagnostic polymorphisms, in 176 POAG patients and 186 matched healthy controls (free of glaucoma by examination) of Saudi Arabia ascendancy. A large sample of 810 healthy Saudi Arabs representing the general Saudi population has also been included in the analysis. Assigning individuals into various mitochondrial haplogroups was performed using the nomenclature previously described for African and for Eurasian sequences.

Results: African mtDNA haplotypes belonging to L haplogroups, excluding L2, confer susceptibility to POAG whereas the Eurasian haplogroup N1 was associated with reduced risk of developing POAG in Saudi Arabian population.

Conclusions: Saudi individuals with mtDNA of African origin are at higher risk of developing POAG. In addition, the mtDNA Eurasian haplogroup N1 may play a mild protective effect to this illness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Africa / ethnology
  • African Continental Ancestry Group
  • Arabs*
  • Case-Control Studies
  • DNA, Mitochondrial / genetics*
  • European Continental Ancestry Group
  • Female
  • Genetic Predisposition to Disease
  • Glaucoma, Open-Angle / ethnology
  • Glaucoma, Open-Angle / genetics*
  • Haplotypes
  • Humans
  • Male
  • Mitochondria / genetics*
  • Open Reading Frames
  • Polymorphism, Genetic
  • Risk Factors
  • Saudi Arabia / epidemiology

Substances

  • DNA, Mitochondrial