The results showed that the mean value of cAMP content in rats endbrain treated by electroacupuncture was obviously reduced than control group. The content of cAMP in the diencephalon and brain stem, the activity of Na(+)-K(+)-ATPase in the whole brain were raised and they show the positive relation with the excite intensity respectively. These experimental results might be taken as a basis for using the hand electroacupuncture for treatment of schizophrenia, manic state and depressive state. This experiment showed the treatment mechanisms of the hand electroacupuncture in accordance with ECT therapy.