Perisomatic inhibition and cortical circuit dysfunction in schizophrenia

Curr Opin Neurobiol. 2011 Dec;21(6):866-72. doi: 10.1016/j.conb.2011.05.013. Epub 2011 Jun 15.


Deficits of cognitive control in schizophrenia are associated with altered gamma oscillations in the prefrontal cortex. Paralbumin basket interneurons, which innervate the perisomatic region of pyramidal neurons, appear to play a key role in generating cortical gamma oscillations. In the prefrontal cortex of subjects with schizophrenia, alterations are present in both pre- and post-synaptic markers of the strength of GABA inputs from parvalbumin basket neurons to pyramidal neurons. These alterations may contribute to the neural substrate for impaired gamma oscillations in schizophrenia.

Publication types

  • Review

MeSH terms

  • Humans
  • Neural Pathways / physiopathology*
  • Neurons / pathology
  • Neurons / physiology*
  • Prefrontal Cortex / physiopathology*
  • Schizophrenia / physiopathology*
  • Synaptic Transmission / physiology*