Disseminated and circulating tumor cells in gastrointestinal oncology

Crit Rev Oncol Hematol. 2012 May;82(2):103-15. doi: 10.1016/j.critrevonc.2011.05.008. Epub 2011 Jun 15.


Circulating (CTCs) and disseminated tumor cells (DTCs) are two different steps in the metastatic process. Several recent techniques have allowed detection of these cells in patients, and have generated many results using different isolation techniques in small cohorts. Herein, we review the detection results and their clinical consequence in esophageal, gastric, pancreatic, colorectal, and liver carcinomas, and discuss their possible applications as new biomarkers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gastrointestinal Neoplasms / blood
  • Gastrointestinal Neoplasms / pathology*
  • Gastrointestinal Neoplasms / therapy
  • Humans
  • Neoplastic Cells, Circulating*