Increased prevalence of celiac disease in patients with unexplained infertility in the United States

J Reprod Med. May-Jun 2011;56(5-6):199-203.


Objective: To determine whether there might be an increased prevalence of undiagnosed celiac disease among a population of infertile women using serologic screening.

Study design: A prospective cohort study was performed at an academic infertility clinic in the United States.

Results: The overall prevalence of celiac disease in this population was 2.1% (4/188). There was a significantly increased prevalence (5.9%) of undiagnosed celiac disease among women presenting with unexplained infertility (n = 51).

Conclusion: Women with unexplained infertility are at increased risk for having undiagnosed celiac disease, which may be a potentially modifiable (and treatable) risk factor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Celiac Disease / diagnosis*
  • Celiac Disease / diet therapy
  • Celiac Disease / epidemiology*
  • Diet, Gluten-Free
  • Female
  • Humans
  • Infertility, Female / epidemiology*
  • Irritable Bowel Syndrome / epidemiology
  • Minnesota / epidemiology
  • Pregnancy
  • Pregnancy Rate
  • Prevalence
  • Prospective Studies