Repeat traumatic brain injury in the developing brain

Int J Dev Neurosci. 2012 May;30(3):185-90. doi: 10.1016/j.ijdevneu.2011.05.009. Epub 2011 May 27.


The Center for Disease Control estimates that there are 1.7 million brain injuries in the US each year with 51% of these injuries occurring during periods of cerebral development. Among this population there is a growing population of individuals with repeat traumatic brain injury (RTBI). While the exact incidence is unknown, estimates range from 5.6 to 36% of the TBI population. This review summarizes the clinical problems/challenges and experimental research models that currently exist. It is intended to reveal the critical areas that need to be addressed so that age-relevant clinical management guidelines can be established to protect this population.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / pathology*
  • Brain / pathology*
  • Brain / physiopathology*
  • Brain Injuries / pathology*
  • Brain Injuries / physiopathology*
  • Humans
  • Models, Neurological*
  • Recurrence