Similar effects of roux-en-Y gastric bypass and vertical sleeve gastrectomy on glucose regulation in rats

Physiol Behav. 2011 Nov 30;105(1):120-3. doi: 10.1016/j.physbeh.2011.05.026. Epub 2011 Jun 12.


Bariatric surgery is the most efficacious procedure for eliciting weight loss in humans, and many patients undergoing the procedure experience significant lessening of their symptoms of type-2 diabetes in addition to losing weight. We have adapted two bariatric surgical procedures commonly employed in humans to a rat model to begin to understand the mechanisms underlying the improvements in energy homeostasis. Young adult male rats received either roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) and were assessed for body weight, food intake and parameters of glucose homeostasis over a 28-week period. Control rats received either a sham surgical procedure or else were unoperated. RYGB and VSG had comparable beneficial effects relative to controls. They ate less food and lost more weight, and they both had improved glucose parameters. The most intriguing aspect of the findings is that the two surgical procedures had such similar effects in spite of quite different rearrangements of the gastrointestinal system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Weight / physiology
  • Energy Metabolism / physiology*
  • Gastrectomy* / methods
  • Gastric Bypass* / methods
  • Glucagon-Like Peptide 1 / metabolism
  • Glucose / metabolism*
  • Homeostasis / physiology
  • Insulin / metabolism*
  • Male
  • Rats
  • Rats, Long-Evans


  • Insulin
  • Glucagon-Like Peptide 1
  • Glucose