Atherosclerosis in psoriatic arthritis

Autoimmun Rev. 2011 Oct;10(12):773-8. doi: 10.1016/j.autrev.2011.05.022. Epub 2011 Jun 13.


The atherosclerotic process is accelerated in several autoimmune rheumatic diseases. Effector cells of innate and adaptive immunity along with pro-inflammatory cytokines and other immune mediators are found in atherosclerotic lesions, where they play an important role in induction, progression and rupture of plaques. Psoriatic arthritis (PsA) is a chronic inflammatory disease, characterized by arthritis, enthesitis, dactilytis, osteitis, and axial involvement, along with skin manifestations. PsA is frequently associated with obesity, diabetes, dyslipidemia, hypertension, accelerated atherosclerosis and with increased cardiovascular morbidity and mortality. Disease-specific and traditional risk factors seem to account for the atherosclerotic burden in PsA patients. Some immunological factors which are involved in PsA can also contribute to atherosclerosis including C reactive protein (CRP), TNF-α, IFN-γ, IL-1, Il 6, IL23, and Th17.

Publication types

  • Review

MeSH terms

  • Adult
  • Arthritis, Psoriatic / complications*
  • Arthritis, Psoriatic / immunology
  • Atherosclerosis / complications*
  • Atherosclerosis / immunology
  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / immunology
  • Female
  • Humans
  • Immunologic Factors
  • Inflammation / complications
  • Inflammation / immunology
  • Male
  • Middle Aged
  • Risk Factors


  • Immunologic Factors