2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

Abdelselam Ali; Teresa Cablewski; Craig L Francis; Ashit K Ganguly; Roger M Sargent; David G Sawutz; Kevin N Winzenberg

doi:10.1016/j.bmcl.2011.05.096

2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4160-3. doi: 10.1016/j.bmcl.2011.05.096. Epub 2011 Jun 1.

Authors

Abdelselam Ali¹, Teresa Cablewski, Craig L Francis, Ashit K Ganguly, Roger M Sargent, David G Sawutz, Kevin N Winzenberg

Affiliation

¹ CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, VIC 3168, Australia.

PMID: 21684739
DOI: 10.1016/j.bmcl.2011.05.096

Abstract

A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin.

MeSH terms

Animals
Antinematodal Agents / chemical synthesis
Antinematodal Agents / chemistry*
Antinematodal Agents / pharmacology
Haemonchus / drug effects*
Haemonchus / growth & development
Ivermectin / chemistry
Ivermectin / pharmacology
Larva / drug effects
Pyridazines / chemical synthesis
Pyridazines / chemistry*
Pyridazines / pharmacology
Structure-Activity Relationship

Substances

Antinematodal Agents
Pyridazines
pyridazine
Ivermectin