Abstract
A series of 6-aryl-5-cyano-2-thiouracil derivatives (1a-d) was synthesized by the reaction of ethyl cyanoacetate with thiourea and aldehydes. These products were used as intermediate compounds for the synthesis of a number of thiouracil derivatives (2a-d to 10a-d). All compounds were screened for antibacterial and antifungal activities. Some of the prepared compounds, 6-(4-fluorophenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (2a), 4-oxo-2-thioxo-6-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide (2d), 6-(4-fluorophenyl)-4-hydrazino-2-thioxo-1,2-dihydropyrimidine-5-cabonitrile (7a) and 4-hydrazino-2-thioxo-6-(3,4,5-trimethoxyphenyl)-1,2-dihydropyrimidine-5-carbonitrile (7d) revealed promising antimicrobial activity.
MeSH terms
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Acetates / chemistry
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Aldehydes / chemistry
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Bacillales / drug effects
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Chemical Phenomena
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Disk Diffusion Antimicrobial Tests
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Drug Design
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Escherichia coli / drug effects
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Indicators and Reagents / chemistry
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mitosporic Fungi / drug effects
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Molecular Structure
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Nitriles / chemical synthesis*
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Nitriles / chemistry
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Nitriles / pharmacology*
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Spectrophotometry, Infrared
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Structure-Activity Relationship
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Thiourea / chemistry
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Transition Temperature
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Uracil / analogs & derivatives*
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Uracil / chemistry
Substances
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Acetates
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Aldehydes
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Anti-Bacterial Agents
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Antifungal Agents
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Indicators and Reagents
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Nitriles
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5-cyanouracil
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Uracil
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Thiourea
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ethyl cyanoacetate