Thrombosis and inflammatory complications are concomitant to the post-surgery period of splenectomy due to the traumatic damage to the spleen. Therefore morphological analysis of the spleen residue after the partial spleen resection is of particular theoretical and practical interest. Total of 36 white rats, male, body mass 130-150 g., underwent partial resection of the spleen under the ether narcosis. Rats were withdrawn from the experiment on the first, 7-th, 15-th, 30-th, 90-th and 180-th day after the surgery. Spleen tissue samples were fixed in the 10% formaldehyde solution and stained with the use of routine methods. Homory method was used to reveal the argyrofilous fibers and ink injection was used to reveal blood vessels respectively. Spleen parameters were calculated morphometrically. Microsoft Excel program was used for statistical analysis of the data obtained. Partial disorder of blood microcirculation in the spleen after partial splenectomy was registered and in same time relative increase in the mass of the spleen and lymphatic follicles was shown concomitant to these disorders. The presence of the clusters of macrophages and lymphocytes capable of phagocytosis, as well as haemociderosis is considered as morphological criterion of the immune reaction. We can suppose that remainder spleen cells can induce immune response as regards autoantigens as response to the operational trauma and directed to restore the homeostasis.