Cocos: Constructing multi-domain protein phylogenies

PLoS Curr. 2011 Jun 9:3:RRN1240. doi: 10.1371/currents.RRN1240.


Phylogenies of multi-domain proteins have to incorporate macro-evolutionary events, which dramatically increases the complexity of their construction.We present an application to infer ancestral multi-domain proteins given a species tree and domain phylogenies. As the individual domain phylogenies are often incongruent, we provide diagnostics for the identification and reconciliation of implausible topologies. We implement and extend a suggested algorithmic approach by Behzadi and Vingron (2006).