Prevalence of natural infection with simian immunodeficiency virus and simian T-cell leukemia virus type I in a breeding colony of sooty mangabey monkeys

AIDS. 1990 Jul;4(7):619-25. doi: 10.1097/00002030-199007000-00002.


The seroprevalence of antibodies to simian immunodeficiency virus (SIVsmm) and simian T-cell leukemia virus type I (STLV-I) in a captive breeding colony of sooty mangabey monkeys was determined, and infection by SIVsmm was confirmed in all cases by virus isolation. Among 138 animals tested, 57 and 33% were infected with SIVsmm and STLV-I, respectively. While the proportion of female mangabeys (66%) differed significantly (P less than 0.01) from the proportion of male mangabeys (42%) infected with SIVsmm, the proportions of males and females infected with STLV-I were similar, suggesting independent transmission of the two viruses. Among mangabeys less than 1 year old, none were infected with STLV-I and only five of 27 mangabeys, all of which were at least 6 months old when first tested, were infected with SIVsmm. The data document that natural infection of sooty mangabey monkeys with SIVsmm or in association with STLV-I infection does not result in increased disease or mortality, and that transmission of both SIVsmm and STLV-I appears to occur primarily through sexual activity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Viral / isolation & purification
  • Cercopithecidae / microbiology*
  • Female
  • Lymphocytes / immunology
  • Lymphocytes / microbiology
  • Male
  • Monkey Diseases / immunology
  • Monkey Diseases / microbiology*
  • Monkey Diseases / transmission
  • Retroviridae Infections / immunology
  • Retroviridae Infections / microbiology
  • Retroviridae Infections / veterinary*
  • Retroviruses, Simian / isolation & purification*
  • Simian Immunodeficiency Virus / immunology
  • Simian Immunodeficiency Virus / isolation & purification*
  • Simian T-lymphotropic virus 1 / immunology
  • Simian T-lymphotropic virus 1 / isolation & purification*


  • Antibodies, Viral