An alternative to treat palmar hyperhidrosis: use of oxybutynin

Clin Auton Res. 2011 Dec;21(6):389-93. doi: 10.1007/s10286-011-0128-4. Epub 2011 Jun 19.


Purpose: To evaluate the effectiveness and patient satisfaction with the use of oxybutynin at low doses for treating palmar hyperhidrosis in a large series of patients.

Methods: From January 2007 to June 2009, 180 consecutive patients with palmar hyperhidrosis were treated with oxybutynin. Data were collected from 139 patients (41 patients were lost to follow-up). During the first week, patients received 2.5 mg of oxybutynin once per day; from the 8th to the 42nd day, 2.5 mg twice per day; and from the 43rd day to the end of the 12th week, 5 mg, twice per day. All of the patients underwent three evaluations before and after the oxybutynin treatment (at 6 and 12 weeks), using a clinical questionnaire and a clinical protocol for quality of life (QOL).

Results: More than 80% of the patients experienced an improvement in palmar hyperhidrosis. Most of the patients showed improvements in their QOL (74.6%). The side effects were minor, with dry mouth being the most frequent (70.5%).

Conclusion: The use of oxybutynin is an alternative as the first step in the treatment of palmar hyperhidrosis, given that it presents good results and improves QOL.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Epidermis / drug effects
  • Hand / pathology*
  • Humans
  • Hyperhidrosis / drug therapy*
  • Mandelic Acids / therapeutic use*
  • Middle Aged
  • Parasympatholytics / pharmacology
  • Parasympatholytics / therapeutic use*
  • Quality of Life
  • Treatment Outcome


  • Mandelic Acids
  • Parasympatholytics
  • oxybutynin