Autoantibodies against neutrophil cytoplasm components in systemic lupus erythematosus and in hydralazine-induced lupus

Clin Exp Immunol. 1990 Sep;81(3):380-3. doi: 10.1111/j.1365-2249.1990.tb05342.x.


Anti-neutrophil cytoplasm antibody (ANCA) has been shown to be no marker of systemic lupus erythematosus (SLE) including lupus nephritis or of progressive systemic sclerosis (PSS). Antibodies against myeloperoxidase (anti-MPO) and elastase, two granulocyte lysosomal enzymes, were found in patients with SLE but not in those with PSS, except for one patient who had anti-MPO. Anti-MPO was present in 21% of patients with SLE, and at low concentrations in about 80% of these cases. Anti-elastase was found in four patients with SLE. In another group of six patients with a SLE-like syndrome induced by anti-hypertensive treatment with the anti-hypertensive hydralazine, anti-MPO antibodies occurred in all six, and anti-elastase antibodies in five. Monitored during a 2-year follow-up period, anti-MPO antibodies were found to persist, whereas anti-elastase antibodies were rapidly eliminated, after withdrawal of the drug.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / metabolism*
  • Autoantigens / immunology
  • Cytoplasm / enzymology
  • Cytoplasm / immunology
  • Female
  • Follow-Up Studies
  • Humans
  • Hydralazine / adverse effects*
  • Lupus Erythematosus, Systemic / chemically induced
  • Lupus Erythematosus, Systemic / enzymology
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • Neutrophils / enzymology
  • Neutrophils / immunology*
  • Pancreatic Elastase / immunology
  • Peroxidase / immunology
  • Scleroderma, Systemic / immunology


  • Autoantibodies
  • Autoantigens
  • Hydralazine
  • Peroxidase
  • Pancreatic Elastase