Nickel-catalyzed amination of aryl phosphates through cleaving aryl C-O bonds

Jin-Hua Huang; Lian-Ming Yang

doi:10.1021/ol201437g

Nickel-catalyzed amination of aryl phosphates through cleaving aryl C-O bonds

Org Lett. 2011 Jul 15;13(14):3750-3. doi: 10.1021/ol201437g. Epub 2011 Jun 20.

Authors

Jin-Hua Huang¹, Lian-Ming Yang

Affiliation

¹ Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

PMID: 21688805
DOI: 10.1021/ol201437g

Abstract

The amination of triaryl phosphates was achieved using a Ni(II)-(σ-Aryl) complex/NHC catalyst system in dioxane at 110 °C in the presence of NaH as base. Electron-neutral, -rich, and -deficient triaryl phosphates were coupled with a wider range of amine partners including cyclic and acyclic secondary amines, aliphatic primary amines, and anilines in good to excellent yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Amines / chemical synthesis*
Amines / chemistry
Catalysis
Combinatorial Chemistry Techniques
Molecular Structure
Nickel / chemistry*
Organophosphorus Compounds / chemistry*

Substances

Amines
Organophosphorus Compounds
Nickel