Heparan sulfate proteoglycans

Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7):a004952. doi: 10.1101/cshperspect.a004952.


Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and coreceptors. Although few in number, heparan sulfate proteoglycans have profound effects at the cellular, tissue, and organismal level.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Adhesion
  • Cell Differentiation
  • Cell Movement
  • Chemokines / metabolism
  • Endocytosis
  • Extracellular Matrix / metabolism
  • Heparan Sulfate Proteoglycans / chemistry
  • Heparan Sulfate Proteoglycans / metabolism
  • Heparan Sulfate Proteoglycans / physiology*
  • Ligands
  • Models, Biological
  • Mutation
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / metabolism
  • Receptors, Cell Surface / physiology*
  • Stem Cells / cytology
  • Substrate Specificity


  • Chemokines
  • Heparan Sulfate Proteoglycans
  • Ligands
  • Receptors, Cell Surface