Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery

Dig Dis. 2011;29(1):48-51. doi: 10.1159/000324128. Epub 2011 Jun 17.


Thirty-five morbidly obese patients underwent Roux-en-Y gastric bypass surgery (RYGB). In addition to weight loss, these patients showed significant improvement of insulin resistance and a reduction of hepatic fat content. Three months after surgery, the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased. FGF19 and FGF21 play a role as regulators of hepatic lipid and glucose metabolism. These results show that RYGB surgery improves metabolism and that this improvement is still apparent 3 months after surgery. Bile salts may play a key role in the improvement of metabolism after RYGB. Why serum bile salt concentrations are elevated after RYGB needs to be investigated.

MeSH terms

  • Bile Acids and Salts / blood
  • Fibroblast Growth Factors / blood*
  • Gastric Bypass*
  • Humans
  • Obesity, Morbid / blood
  • Obesity, Morbid / surgery


  • Bile Acids and Salts
  • FGF19 protein, human
  • fibroblast growth factor 21
  • Fibroblast Growth Factors