Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

Nature. 1978 Nov 9;276(5684):186-8. doi: 10.1038/276186a0.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Clonidine / pharmacology*
  • Clonidine / therapeutic use
  • Humans
  • Locus Coeruleus / physiopathology*
  • Male
  • Morphine / pharmacology
  • Morphine Dependence / physiopathology*
  • Naloxone / antagonists & inhibitors
  • Neurons / physiology
  • Rats
  • Receptors, Adrenergic, alpha / drug effects
  • Receptors, Neurotransmitter / drug effects
  • Receptors, Opioid / drug effects
  • Substance Withdrawal Syndrome / prevention & control

Substances

  • Receptors, Adrenergic, alpha
  • Receptors, Neurotransmitter
  • Receptors, Opioid
  • Naloxone
  • Morphine
  • Clonidine