Structure and absolute configuration of helosides A and B, new saponins from Chamaelirium luteum

Victoria L Challinor; Julia M U Stuthe; Paul V Bernhardt; Reginald P Lehmann; William Kitching; James J De Voss

doi:10.1021/np200100a

Structure and absolute configuration of helosides A and B, new saponins from Chamaelirium luteum

J Nat Prod. 2011 Jul 22;74(7):1557-60. doi: 10.1021/np200100a. Epub 2011 Jun 21.

Authors

Victoria L Challinor¹, Julia M U Stuthe, Paul V Bernhardt, Reginald P Lehmann, William Kitching, James J De Voss

Affiliation

¹ School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane 4072, Australia.

PMID: 21692443
DOI: 10.1021/np200100a

Abstract

Investigation of Chamaelirium luteum roots led to the isolation of two new steroidal saponins, helosides A and B, that contain a previously unreported aglycone, helogenin. Their structures and absolute configuration were elucidated through MS-MS, NMR, chemical degradation, and X-ray crystallography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Crystallography, X-Ray
Liliaceae / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Roots / chemistry
Saponins / chemistry
Saponins / isolation & purification*

Substances

Saponins
heloside A
heloside B