A formal synthesis of SCH 351448

Org Lett. 2011 Jul 15;13(14):3742-5. doi: 10.1021/ol201426c. Epub 2011 Jun 21.

Abstract

An efficient formal synthesis of SCH 351448 was accomplished through the tandem cross-metathesis (CM)/oxa-Michael, the 1,4-syn aldol, the tandem oxidation/oxa-Michael, and the Suzuki coupling reaction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aldehydes / chemistry*
  • Lactones / chemical synthesis*
  • Lactones / chemistry
  • Molecular Structure
  • Oxidation-Reduction
  • Stereoisomerism

Substances

  • Aldehydes
  • Lactones
  • SCH 351448