Aromatase inhibitors in men: effects and therapeutic options

Reprod Biol Endocrinol. 2011 Jun 21;9:93. doi: 10.1186/1477-7827-9-93.

Abstract

Aromatase inhibitors effectively delay epiphysial maturation in boys and improve testosterone levels in adult men Therefore, aromatase inhibitors may be used to increase adult height in boys with gonadotropin-independent precocious puberty, idiopathic short stature and constitutional delay of puberty. Long-term efficacy and safety of the use of aromatase inhibitors has not yet been established in males, however, and their routine use is therefore not yet recommended.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Aromatase Inhibitors / adverse effects
  • Aromatase Inhibitors / therapeutic use*
  • Body Height / drug effects*
  • Bone Development / drug effects
  • Breast / drug effects
  • Child
  • Growth Disorders / drug therapy*
  • Humans
  • Male
  • Obesity / drug therapy
  • Puberty / drug effects*
  • Puberty, Precocious / drug therapy*
  • Spermatogenesis / drug effects
  • Testosterone

Substances

  • Aromatase Inhibitors
  • Testosterone