Acidosis leads to brain dysfunctions through impairing cortical GABAergic neurons

Biochem Biophys Res Commun. 2011 Jul 15;410(4):775-9. doi: 10.1016/j.bbrc.2011.06.053. Epub 2011 Jun 12.

Abstract

Acidosis, associated with metabolic disorders, leads to the pathological changes of cognition and behavior in the clinical practices of neurology and psychology. The cellular mechanisms underlying these cerebral dysfunctions remain unclear. By using electrophysiological approach and changing extracellular pH, we have investigated the effects of acidic environment on cortical GABAergic neurons in terms of their abilities of firing spikes and responses to synaptic inputs. Artificial cerebral spinal fluid in low pH impairs the responses to excitatory synaptic inputs and the abilities of encoding sequential spikes at these GABAergic neurons. The impairments of neuronal spiking are associated with the increases of refractory periods and threshold potentials. Our studies reveal that acidosis may impair cortical GABAergic neurons and in turn deteriorate brain functions, in which their final targets are voltage-gated sodium channels and glutamate receptor-channels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acidosis / complications
  • Acidosis / physiopathology*
  • Animals
  • Brain Diseases / etiology
  • Brain Diseases / physiopathology*
  • Cells, Cultured
  • Cerebral Cortex / physiopathology*
  • Hydrogen-Ion Concentration
  • Mice
  • Mice, Inbred Strains
  • Neurons / physiology*
  • Synaptic Transmission
  • gamma-Aminobutyric Acid / physiology*

Substances

  • gamma-Aminobutyric Acid