Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis

Chem Phys Lipids. 2011 Sep;164(6):500-14. doi: 10.1016/j.chemphyslip.2011.06.004. Epub 2011 Jun 12.

Abstract

De novo fatty acid biosynthesis is also called lipogenesis. It is a metabolic pathway that provides the cells with fatty acids required for major cellular processes such as energy storage, membrane structures and lipid signaling. In this article we will review the role of the Liver X Receptors (LXRs), nuclear receptors that sense oxysterols, in the transcriptional regulation of genes involved in lipogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cholesterol / metabolism*
  • Fatty Acids / biosynthesis
  • Fatty Acids / chemistry
  • Fatty Acids / metabolism
  • Humans
  • Ligands
  • Lipogenesis*
  • Liver / metabolism
  • Liver X Receptors
  • Orphan Nuclear Receptors / metabolism*

Substances

  • Fatty Acids
  • Ligands
  • Liver X Receptors
  • Orphan Nuclear Receptors
  • Cholesterol