Enhanced platelet reactivity in cats experimentally infected with feline infectious peritonitis virus

Vet Pathol. 1990 Jul;27(4):269-73. doi: 10.1177/030098589002700408.


Platelet function was evaluated in six specific-pathogen-free cats prior to and following intraperitoneal inoculation with feline infectious peritonitis virus (FIPV). By 4 days post-inoculation, platelet samples from five of six cats responded with irreversible platelet aggregation to threshold concentrations of adenosine diphosphate (ADP). This was accompanied by enhanced platelet 14C-serotonin release (greater than 10%) in two cats. Compared to one of six baseline samples, five of five post-inoculation samples exhibited microaggregate formation in response to 20 microM epinephrine. Enhanced platelet 14C-serotonin release did not accompany these responses. Enhanced platelet responses to ADP and epinephrine were also observed on day 11 post-inoculation and day 16 (when one cat died) or 21 (the end of the study). Platelet 14C-serotonin release in response to 20 microM epinephrine increased markedly in three of five cats on day 21. Enhanced collagen-induced platelet responses were not demonstrated. Although the mechanism for the enhanced platelet responses observed on day 4 was unknown, a direct effect on the virus on platelets, mononuclear inflammatory cells, and endothelial cells must be considered.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Diphosphate / pharmacology
  • Animals
  • Cat Diseases / blood*
  • Cat Diseases / pathology
  • Cats
  • Collagen / pharmacology
  • Coronaviridae Infections / blood
  • Coronaviridae Infections / pathology
  • Coronaviridae Infections / veterinary*
  • Epinephrine / pharmacology
  • Peritonitis / blood
  • Peritonitis / pathology
  • Peritonitis / veterinary*
  • Platelet Aggregation* / drug effects
  • Serotonin / blood
  • Specific Pathogen-Free Organisms


  • Serotonin
  • Adenosine Diphosphate
  • Collagen
  • Epinephrine