Comparison of single-dose and multiple-dose antibiotics for lower urinary tract infection in pregnancy

Int J Gynaecol Obstet. 2011 Sep;114(3):229-33. doi: 10.1016/j.ijgo.2011.03.014. Epub 2011 Jun 22.

Abstract

Objective: To compare the efficacy of fosfomycin trometamol, cefuroxime axetil, and amoxicillin clavulanate antibiotics, and to assess the difference in patient compliance, in the treatment of urinary tract infections during pregnancy.

Methods: Between September 2007 and May 2008, 90 out of 324 pregnant women with complaints of lower urinary tract infection, who were followed at the outpatient clinic or referred to the emergency department of Vakif Gureba Education and Research Hospital, were enrolled in a prospective study. Patients were randomized into 3 equal groups for treatment with single-dose fosfomycin trometamol, or 5-day courses of amoxicillin clavulanate or cefuroxime axetil. After follow-up, study data were obtained for 28, 27, and 29 patients, respectively.

Results: The treatment groups did not differ significantly in terms of demographics, clinical success rate, microbiological cure rate, or adverse effects. Significantly higher drug compliance was observed in the fosfomycin trometamol group than in the other 2 groups (P<0.05).

Conclusion: Treatment with a single dose of fosfomycin trometamol was as effective for UTI as the standard course of treatment with amoxicillin clavulanate or cefuroxime axetil. Fosfomycin trometamol may be a preferable treatment for UTI because of its simpler use and better rates of compliance.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Amoxicillin-Potassium Clavulanate Combination / administration & dosage
  • Anti-Bacterial Agents / administration & dosage*
  • Cefuroxime / administration & dosage
  • Cefuroxime / analogs & derivatives
  • Female
  • Fosfomycin / administration & dosage
  • Humans
  • Patient Compliance / statistics & numerical data
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / microbiology
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Fosfomycin
  • Amoxicillin-Potassium Clavulanate Combination
  • Cefuroxime
  • cefuroxime axetil