Abstract
In a survey of the pertinent literature the pharmacological and toxicodynamic, effects, metabolism and mechanism of action of diazepam in experimental animals and humans are discussed. Particular attention is paid to the effects of diazepam given during the developmental age on the development and function of the central nervous system in mammals.
MeSH terms
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Animals
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Anxiety / drug therapy*
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Anxiety / metabolism
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Brain / drug effects*
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Brain / metabolism
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Diazepam / pharmacokinetics
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Diazepam / pharmacology
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Diazepam / therapeutic use*
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Female
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Fetus / drug effects*
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Fetus / metabolism
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Humans
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Infant, Newborn / metabolism*
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Maternal-Fetal Exchange / drug effects
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Maternal-Fetal Exchange / physiology
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Pregnancy
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Pregnancy Complications / drug therapy*
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Pregnancy Complications / metabolism
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Rats
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Receptors, GABA-A / drug effects*
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Receptors, GABA-A / metabolism
Substances
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Receptors, GABA-A
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Diazepam