Rheumatologic manifestations of human parvovirus B19 infection in adults. Initial two-year clinical experience

Arthritis Rheum. 1990 Sep;33(9):1297-309. doi: 10.1002/art.1780330901.


During 1987 and 1988, we identified 9 adults at the Medical and Rheumatology Services of the University of Iowa Hospitals and Clinics who had a clinical diagnosis of fifth disease; 8 of the 9 had symptoms of joint involvement. Another 12 adults with serologic positivity for anti-parvovirus B19 IgM antibody presented with polyarthralgia/polyarthritis. Patients were usually found to be seronegative for rheumatoid factor, and none developed nodules or erosive disease. Many patients with chronic disease met criteria for a diagnosis of rheumatoid arthritis. A diagnosis of parvovirus B19 infection should be considered during the initial visit of patients with polyarthralgia/polyarthritis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antibodies, Viral / analysis
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Erythema / microbiology
  • Humans
  • Immunoglobulin G / analysis
  • Immunoglobulin M / analysis
  • Joint Diseases / microbiology*
  • Parvoviridae Infections* / diagnosis


  • Antibodies, Viral
  • Immunoglobulin G
  • Immunoglobulin M