Type V collagen genotype and exercise-related phenotype relationships: a novel hypothesis

Exerc Sport Sci Rev. 2011 Oct;39(4):191-8. doi: 10.1097/JES.0b013e318224e853.


We have shown that a variant within COL5A1, which encodes a subunit of type V collagen, is associated with injury and performance phenotypes. Although seemingly unrelated, these phenotypes are associated directly or indirectly with the mechanical properties of musculoskeletal soft tissue. We therefore hypothesize that variants in the COL5A1 gene alter fibril architecture and structure and, thereby, mechanical properties.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 3' Untranslated Regions
  • Athletic Injuries / genetics*
  • Collagen Type V / genetics*
  • Exercise*
  • Humans
  • Muscle, Skeletal / physiology*
  • Phenotype


  • 3' Untranslated Regions
  • COL5A1 protein, human
  • Collagen Type V