Toward a modern synthesis of immunity: Charles A. Janeway Jr. and the immunologist's dirty little secret

Yale J Biol Med. 2011 Jun;84(2):131-8.


This essay chronicles the major theoretical and experimental contributions made by Charles A. Janeway, Jr. (1943-2003), Howard Hughes Medical Institute investigator and Yale Professor of Immunobiology, who established the fundamental role of the innate immune system in the induction of the adaptive arm.

Keywords: B7 molecules; Janeway; Medzhitov; Toll-like receptors; co-stimulation; induction; infectious non-self; non-infectious self; pathogen-associated molecular patterns; pattern recognition receptor; signal 1; signal 2; two-signal hypothesis.

Publication types

  • Biography
  • Historical Article

MeSH terms

  • Allergy and Immunology / history
  • Connecticut
  • History, 20th Century
  • History, 21st Century
  • Immune System / immunology
  • Immunity, Innate / immunology*
  • United States
  • Universities / history

Personal name as subject

  • Charles Janeway