Abstract
The proinflammatory chemokine interleukin-8 is increased in asthmatic patients. Traditionally, ginger is used as an antiinflammatory drug. An extract and several compounds of Zingiber officinale (ginger) were tested in human bronchial epithelial cells (BEAS-2B cells) with respect to their effect on lipopolysaccharide (LPS)-induced secretion of the proinflammatory chemokine interleukin 8 (IL-8) and RANTES (regulated upon activation, normal T-cell expressed and secreted). An oily extract of ginger rhizome with > 25% total pungent compounds, ginger volatile oil, ar-curcumene and α-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and β-phellandrene showed no effect. The LPS-induced slight increase of RANTES was reduced by volatile oil, ar-curcumene and α-pinene. There was no effect of LPS on TNF-α. Our results suggest that distinct ginger compounds could be used as antiinflammatory drugs in respiratory infections.
Copyright © 2011 John Wiley & Sons, Ltd.
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Bicyclic Monoterpenes
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Bronchi / cytology*
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Bronchi / immunology
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Catechols / chemistry
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Catechols / pharmacology
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Cell Line
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Chemokine CCL5 / immunology
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Cyclohexane Monoterpenes
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Cyclohexenes / chemistry
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Dose-Response Relationship, Immunologic
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Enzyme-Linked Immunosorbent Assay
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Epithelial Cells / cytology
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Epithelial Cells / drug effects*
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Epithelial Cells / immunology
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Fatty Alcohols / chemistry
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Fatty Alcohols / pharmacology
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Humans
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Interleukin-8 / immunology
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Interleukin-8 / metabolism
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Lipopolysaccharides / immunology
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Monoterpenes / chemistry
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Plant Oils / chemistry
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Plant Oils / pharmacology
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Pseudomonas aeruginosa / chemistry
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Rhizome / chemistry
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Sesquiterpenes / chemistry
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Sesquiterpenes / pharmacology
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Volatile Organic Compounds / chemistry
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Volatile Organic Compounds / pharmacology
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Zingiber officinale / chemistry*
Substances
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Anti-Inflammatory Agents
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Bicyclic Monoterpenes
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CCL5 protein, human
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Catechols
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Chemokine CCL5
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Cyclohexane Monoterpenes
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Cyclohexenes
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Fatty Alcohols
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Interleukin-8
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Lipopolysaccharides
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Monoterpenes
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Plant Extracts
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Plant Oils
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Sesquiterpenes
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Volatile Organic Compounds
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beta-phellandrene
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alpha-curcumene
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shogaol
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gingerol
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alpha-pinene