Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells

Phytother Res. 2012 Mar;26(3):333-6. doi: 10.1002/ptr.3558. Epub 2011 Jun 23.

Abstract

The proinflammatory chemokine interleukin-8 is increased in asthmatic patients. Traditionally, ginger is used as an antiinflammatory drug. An extract and several compounds of Zingiber officinale (ginger) were tested in human bronchial epithelial cells (BEAS-2B cells) with respect to their effect on lipopolysaccharide (LPS)-induced secretion of the proinflammatory chemokine interleukin 8 (IL-8) and RANTES (regulated upon activation, normal T-cell expressed and secreted). An oily extract of ginger rhizome with > 25% total pungent compounds, ginger volatile oil, ar-curcumene and α-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and β-phellandrene showed no effect. The LPS-induced slight increase of RANTES was reduced by volatile oil, ar-curcumene and α-pinene. There was no effect of LPS on TNF-α. Our results suggest that distinct ginger compounds could be used as antiinflammatory drugs in respiratory infections.

MeSH terms

  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • Bicyclic Monoterpenes
  • Bronchi / cytology*
  • Bronchi / immunology
  • Catechols / chemistry
  • Catechols / pharmacology
  • Cell Line
  • Chemokine CCL5 / immunology
  • Cyclohexane Monoterpenes
  • Cyclohexenes / chemistry
  • Dose-Response Relationship, Immunologic
  • Enzyme-Linked Immunosorbent Assay
  • Epithelial Cells / cytology
  • Epithelial Cells / drug effects*
  • Epithelial Cells / immunology
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / pharmacology
  • Ginger / chemistry*
  • Humans
  • Interleukin-8 / immunology
  • Interleukin-8 / metabolism
  • Lipopolysaccharides / immunology
  • Monoterpenes / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Oils / chemistry
  • Plant Oils / pharmacology
  • Pseudomonas aeruginosa / chemistry
  • Rhizome / chemistry
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / pharmacology
  • Volatile Organic Compounds / chemistry
  • Volatile Organic Compounds / pharmacology

Substances

  • Anti-Inflammatory Agents
  • Bicyclic Monoterpenes
  • CCL5 protein, human
  • Catechols
  • Chemokine CCL5
  • Cyclohexane Monoterpenes
  • Cyclohexenes
  • Fatty Alcohols
  • Interleukin-8
  • Lipopolysaccharides
  • Monoterpenes
  • Plant Extracts
  • Plant Oils
  • Sesquiterpenes
  • Volatile Organic Compounds
  • beta-phellandrene
  • alpha-curcumene
  • shogaol
  • gingerol
  • alpha-pinene