SiRNA delivery: challenges and role of carrier systems

Pharmazie. 2011 May;66(5):313-8.

Abstract

Gene silencing by RNA interference is a rapidly growing therapeutic area for managing diseases. Despite research advances in this direction, the poor cellular uptake of synthetic small interfering RNAs is a major impediment to their clinical applications. Polymer and lipid-based systems are attractive carrier systems for delivery of siRNA and provide options for desirable engineering of carrier particles. In this review, there is a detailed discussion of RNAi delivery systems and recent advances in the field.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Carriers*
  • Drug Delivery Systems*
  • Emulsions
  • Gene Targeting / methods
  • Genetic Therapy / methods
  • Humans
  • Lipids / chemistry
  • Liposomes
  • Nanoparticles
  • Polymers / chemistry
  • RNA, Small Interfering / administration & dosage*
  • RNA, Small Interfering / chemistry
  • RNA, Small Interfering / genetics
  • RNA, Small Interfering / therapeutic use

Substances

  • Drug Carriers
  • Emulsions
  • Lipids
  • Liposomes
  • Polymers
  • RNA, Small Interfering