Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: a cross-sectional study

Cardiovasc Diabetol. 2011 Jun 23;10:55. doi: 10.1186/1475-2840-10-55.


Background: Type 2 diabetes is associated with increased levels of Angiopoietin-2 (Ang-2) and soluble Tie-2 (sTie-2), but its impact on vascular disease is still unknown. This study aimed to further explore the associations of Ang-2 and sTie-2 with metabolic control and diabetic complications.

Methods: In a cross-sectional designed study, levels of Ang-2 and sTie-2 as well as their relationships to cardiometabolic parameters were determined in 80 type 2 diabetic subjects (age 65 ± 7 years, female 47.4%).

Results: After controlling for age and BMI, Ang-2 levels were associated with levels of sTie-2, diastolic blood pressure, plasma insulin, homeostasis model assessment of insulin resistance (HOMA-IR), creatinine, glomerular filtration rate (GFR), and gamma-glutamyl transferase (GGT) (all p < 0.02). Presence of diabetic macrovascular complications, polyneuropathy and insulin therapy were associated with higher Ang-2 levels (p < 0.05). Conversely, sTie-2 levels were associated with glycated hemoglobin (HbA1c), fasting plasma glucose and insulin, HOMA-IR, triglyceride, and liver function parameters (all p < 0.03). Multiple linear regression analysis showed that Ang-2 remained significantly associated only with levels of GGT (p < 0.04), whereas sTie-2 remained significantly associated with HbA(1c), insulin levels, and HOMA-IR (p < 0.03). No differences in Ang-2 and sTie-2 levels were observed with regard to gender of participants.

Conclusions: Ang-2 is independently associated with levels of GGT while sTie-2 is independently associated with levels of HbA(1c), plasma insulin and HOMA-IR in type 2 diabetic subjects. Therefore we suggest that the associations of Ang-2 and sTie-2 with type 2 diabetes are based on different patho-physiological mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angiopoietin-2 / blood*
  • Biomarkers / blood
  • Blood Pressure / physiology
  • Cross-Sectional Studies
  • Diabetes Complications / blood
  • Diabetes Complications / epidemiology*
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Female
  • Glomerular Filtration Rate / physiology
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Insulin / blood
  • Insulin Resistance / physiology
  • Male
  • Middle Aged
  • Receptor, TIE-2 / blood*
  • Regression Analysis
  • Risk Factors
  • gamma-Glutamyltransferase / blood


  • Angiopoietin-2
  • Biomarkers
  • Glycated Hemoglobin A
  • Insulin
  • gamma-Glutamyltransferase
  • gamma-glutamyltransferase, human
  • Receptor, TIE-2