Pro-senescence therapy for cancer treatment

Nat Rev Cancer. 2011 Jun 24;11(7):503-11. doi: 10.1038/nrc3057.


Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle
  • Cellular Senescence*
  • Genes, myc
  • Humans
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Neoplasms / therapy*
  • Neoplastic Stem Cells / pathology
  • PTEN Phosphohydrolase / physiology
  • Tumor Suppressor Protein p53 / physiology


  • Tumor Suppressor Protein p53
  • PTEN Phosphohydrolase