Abstract
The insulinomimetic activity of a Zn(ii) complex is reported. The effects of the Zn(ii) complex with ascorbic acid (Vitamin C; VC), methylmethionine sulfonium chloride (Vitamin U; VU) and l-carnitine were assessed in diet-induced metabolic syndrome model rats. Zn(VU)(2)Cl(2) and Zn(VC)Cl(2) were suggested to be useful supplementary materials for preventing metabolic syndrome by reducing visceral adipose tissues or accelerating blood fluidity.
MeSH terms
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Adipocytes / drug effects
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Adipocytes / metabolism
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Adipose Tissue / drug effects
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Adipose Tissue / metabolism
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Adipose Tissue / pathology
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Animals
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Ascorbic Acid / pharmacology
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Ascorbic Acid / therapeutic use*
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Body Weight / drug effects
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Carnitine / pharmacology
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Carnitine / therapeutic use*
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Cell Separation
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Diet
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Disease Models, Animal
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Fatty Acids / metabolism
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Feeding Behavior / drug effects
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Glucose / pharmacology
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Inhibitory Concentration 50
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Insulin / analogs & derivatives
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Metabolic Syndrome / drug therapy*
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Metabolic Syndrome / prevention & control
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Rats
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Vitamin U / pharmacology
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Vitamin U / therapeutic use*
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Zinc / pharmacology
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Zinc / therapeutic use*
Substances
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Fatty Acids
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Insulin
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Vitamin U
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Glucose
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Zinc
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Ascorbic Acid
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Carnitine