Silicon carbide has been proved as a candidate for power and high-frequency devices. In this paper, we show the application of nanocrystalline 3C-SiC as an electrochemical electrode and its electrochemical functionalization for biosensing applications. SiC electrodes show a wider potential window and lower background current than glassy carbon electrodes. The surface can be electrochemically functionalized with diazonium salts, as confirmed by electrochemical techniques and X-ray photoelectron spectroscopy. The nitrophenyl film is used as linker layer to bond DNA molecule to SiC. These results show that 3C-SiC can be an interesting transducer material for applications in electro- and bioelectrochemical applications.