p63 and epithelial metaplasia: a gutsy choice

Cell. 2011 Jun 24;145(7):1003-5. doi: 10.1016/j.cell.2011.06.008.


Barrett's esophagus is an epithelial metaplasia associated with an increased risk for cancer, but its underlying mechanisms have been debated. Now Wang et al. (2011) suggest an intriguing explanation for this puzzle: a population of residual embryonic cells, lacking the transcription factor p63, migrates and repopulates a normal tissue damaged by inflammation or gastroesophageal reflux.

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