The Y chromosome in the era of intracytoplasmic sperm injection: a personal review

Fertil Steril. 2011 Jun 30;95(8):2439-48.e1-5. doi: 10.1016/j.fertnstert.2011.05.070.

Abstract

The Y chromosome contains 60 multicopy genes composed of nine different gene families concentrated in regions of multiple repeat sequences called amplicons arranged in mirror images called palindromes. This pattern is susceptible to deletions caused by homologous recombination with itself, and can explain the presence of small numbers of sperm in otherwise azoospermic men.

Publication types

  • Review

MeSH terms

  • Animals
  • Azoospermia / genetics
  • Azoospermia / physiopathology
  • Azoospermia / therapy*
  • Chromosome Deletion
  • Chromosomes, Human, Y*
  • Female
  • Genetic Predisposition to Disease
  • Heredity
  • Hominidae
  • Humans
  • Male
  • Phenotype
  • Pregnancy
  • Recombination, Genetic
  • Sperm Count
  • Sperm Injections, Intracytoplasmic*
  • Spermatogenesis / genetics*