Randomized trial on endoscopic resection-cap versus multiband mucosectomy for piecemeal endoscopic resection of early Barrett's neoplasia

Gastrointest Endosc. 2011 Jul;74(1):35-43. doi: 10.1016/j.gie.2011.03.1243.


Background: Endoscopic resection (ER) is an important treatment for high-grade intraepithelial neoplasia and early cancer in Barrett's esophagus. ER-cap requires submucosal lifting and positioning of a snare in the cap, making it technically demanding and laborious. Multiband mucosectomy (MBM) uses a modified variceal band ligator and requires no submucosal lifting or positioning of a snare.

Objective: To compare ER-cap and MBM for piecemeal ER of early Barrett's neoplasia.

Design: Randomized, controlled trial.

Setting: Tertiary-care and community-care centers.

Patients: This study involved 84 patients (64 men; median age 70 years) undergoing piecemeal ER of Barrett's neoplasia.

Intervention: Piecemeal ER was performed by using ER-cap (n = 42) or MBM (n = 42).

Main outcome measurements: Safety, efficacy, procedure time, costs.

Results: Procedure time (34 vs 50 minutes; P = .02) and costs (€240 vs €322; P < .01) were significantly less with MBM compared with ER-cap. MBM resulted in smaller resection specimens than ER-cap (18 ×13 mm vs 20 × 15 mm; P < .01). Maximum thicknesses of specimens and resected submucosa were not significantly different. There were no clinically relevant bleeding episodes. Four perforations occurred, 3 with ER-cap, 1 with MBM (P = not significant).

Limitations: Potential bias because of different levels of experience among participating endoscopists.

Conclusion: Piecemeal ER with MBM is faster and cheaper than with ER-cap. Despite the lack of submucosal lifting, MBM appears not to be associated with more perforations. Although MBM results in slightly smaller specimens, the clinical relevance of this may be limited because depth of resections does not differ between both techniques. MBM may thus be preferred for piecemeal ER of early Barrett's neoplasia. (

Clinical trial registration number: NTR1435.).

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Barrett Esophagus / surgery*
  • Esophagoscopy / adverse effects
  • Esophagoscopy / methods*
  • Female
  • Humans
  • Male
  • Mucous Membrane / surgery
  • Prospective Studies