Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women

J Epidemiol. 2011;21(5):329-36. doi: 10.2188/jea.JE20100188. Epub 2011 Jun 25.


Background: B vitamins, including vitamin B(6), are coenzymes that are important for DNA integrity and stability. Deficiencies in B vitamins may promote tumor carcinogenesis.

Methods: We examined the association of dietary vitamin B(6) intake with overall breast cancer risk and breast cancers stratified by hormone receptor status. This case-control study included 391 breast cancer cases and 782 control subjects enrolled at the Tri-Service General Hospital in Taipei, Taiwan. Energy-adjusted intake of vitamin B(6) was derived from a food frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.

Results: As compared with women in the lowest tertile, the multivariate-adjusted ORs for breast cancer among women in the second and highest tertiles of vitamin B(6) intake were 0.78 (95% CI, 0.64-2.52) and 0.64 (0.26-0.92), respectively. In addition, higher vitamin B(6) intake was associated with a significantly lower risk of developing ER-negative breast tumors.

Conclusions: Our findings suggest that higher intake of vitamin B(6) is associated with a reduction in breast cancer risk, particularly ER-negative tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / prevention & control*
  • Case-Control Studies
  • Diet Surveys
  • Dietary Supplements*
  • Female
  • Humans
  • Middle Aged
  • Odds Ratio
  • Receptors, Estrogen / metabolism
  • Risk Factors
  • Taiwan / epidemiology
  • Vitamin B 6 / administration & dosage*
  • Vitamin B Complex / administration & dosage*
  • Young Adult


  • Receptors, Estrogen
  • Vitamin B Complex
  • Vitamin B 6