Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans

Nat Neurosci. 2011 Jun 26;14(8):984-92. doi: 10.1038/nn.2854.

Abstract

Animals cope with environmental changes by altering behavioral strategy. Environmental information is generally received by sensory neurons in the neural circuit that generates behavior. However, although environmental temperature inevitably influences an animal's entire body, the mechanism of systemic temperature perception remains largely unknown. We show here that systemic temperature signaling induces a change in a memory-based behavior in C. elegans. During behavioral conditioning, non-neuronal cells as well as neuronal cells respond to cultivation temperature through a heat-shock transcription factor that drives newly identified gene expression dynamics. This systemic temperature signaling regulates thermosensory neurons non-cell-autonomously through the estrogen signaling pathway, producing thermotactic behavior. We provide a link between systemic environmental recognition and behavioral plasticity in the nervous system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological / genetics
  • Adaptation, Physiological / physiology*
  • Animals
  • Animals, Genetically Modified
  • Behavior, Animal / physiology
  • Body Temperature / drug effects
  • Body Temperature / genetics
  • Body Temperature / physiology*
  • Caenorhabditis elegans / physiology
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Calcium / metabolism
  • Down-Regulation / drug effects
  • Down-Regulation / genetics
  • Down-Regulation / physiology
  • Estrogens / metabolism
  • Estrogens / pharmacology
  • Gene Expression Profiling / methods
  • Green Fluorescent Proteins / genetics
  • Heat-Shock Proteins / metabolism
  • Locomotion / drug effects
  • Locomotion / genetics
  • Locomotion / physiology*
  • Mutation / genetics
  • Nerve Net / cytology
  • Nerve Net / physiology
  • Neurons / physiology
  • Oligonucleotide Array Sequence Analysis / methods
  • RNA, Messenger / metabolism
  • Signal Transduction / drug effects
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Temperature
  • Thermosensing / drug effects
  • Thermosensing / genetics
  • Thermosensing / physiology*
  • Time Factors
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Caenorhabditis elegans Proteins
  • Estrogens
  • Heat-Shock Proteins
  • RNA, Messenger
  • Transcription Factors
  • heat shock factor-1, C elegans
  • Green Fluorescent Proteins
  • Calcium

Associated data

  • GEO/GSE28856