A pharmacological approach to first aid treatment for snakebite

Nat Med. 2011 Jun 26;17(7):809-11. doi: 10.1038/nm.2382.

Abstract

Snake venom toxins first transit the lymphatic system before entering the bloodstream. Ointment containing a nitric oxide donor, which impedes the intrinsic lymphatic pump, prolonged lymph transit time in rats and humans and also increased rat survival time after injection of venom. This pharmacological approach should give snakebite victims more time to obtain medical care and antivenom treatment.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Animals
  • Female
  • First Aid / methods*
  • Humans
  • Lymphatic System / drug effects
  • Male
  • Middle Aged
  • Nitric Oxide Donors / administration & dosage
  • Nitric Oxide Donors / therapeutic use*
  • Nitroglycerin / administration & dosage
  • Nitroglycerin / therapeutic use*
  • Ointments
  • Rats
  • Snake Bites / drug therapy*
  • Snake Venoms / administration & dosage
  • Snake Venoms / antagonists & inhibitors
  • Snake Venoms / pharmacokinetics
  • Young Adult

Substances

  • Nitric Oxide Donors
  • Ointments
  • Snake Venoms
  • Nitroglycerin