Recognition of thymine in DNA bulges by a Zn(II) macrocyclic complex

Chem Commun (Camb). 2011 Aug 14;47(30):8566-8. doi: 10.1039/c1cc12074c. Epub 2011 Jun 27.

Abstract

A Zn(II) macrocyclic complex with appended quinoline is a bifunctional recognition agent that uses both the Zn(II) center and the pendent aromatic group to bind to thymine in bulges with good selectivity over DNA containing G, C or A bulges. Spectroscopic studies show that the stem containing the bulge stays largely intact in a DNA hairpin with the Zn(II) complex bound to the thymine bulge.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Coordination Complexes / chemistry*
  • DNA / chemistry*
  • Macrocyclic Compounds / chemistry*
  • Oligonucleotides / chemistry
  • Quinolines / chemistry
  • Thymine / chemistry*
  • Zinc / chemistry*

Substances

  • Coordination Complexes
  • Macrocyclic Compounds
  • Oligonucleotides
  • Quinolines
  • DNA
  • quinoline
  • Zinc
  • Thymine