Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for pancreatic neuroendocrine tumors

J Clin Oncol. 2011 Aug 1;29(22):3044-9. doi: 10.1200/JCO.2011.35.1817. Epub 2011 Jun 27.


Purpose: The American Joint Committee on Cancer (AJCC) staging manual (seventh edition) has introduced its first TNM staging classification for pancreatic neuroendocrine tumors (NETs) derived from the staging algorithm for exocrine pancreatic adenocarcinomas. This classification has not yet been validated.

Methods: Patients with pancreatic NETs treated at the H. Lee Moffitt Cancer Center between 1999 and 2010 were assigned a stage (I to IV) based on the new AJCC classification. Kaplan-Meier analyses for overall survival (OS) were performed based on age, race, histologic grade, incidental diagnosis, and TNM staging (European Neuroendocrine Tumors Society [ENETS] v AJCC) using log-rank tests. Survival time was measured from time of initial diagnosis to date of last contact or date of death. Multivariate modeling was performed using Cox proportional hazards regression. Weighted Cohen's κ coefficient was computed to evaluate the agreement of ENETS and AJCC classifications.

Results: We identified 425 patients with pancreatic NETs. On the basis of histopathologic grade, 5-year survival rates for low-, intermediate-, and high-grade tumors were 75%, 62%, and 7%, respectively (P < .001). When using the ENETS classification, 5-year OS rates for stages I, II, III, and IV were 100%, 88%, 85%, and 57%, respectively (P < .001). Subsequently, using the AJCC classification, 5-year OS rates for stages I, II, III, and IV were 92%, 84%, 81%, and 57%, respectively (P < .001). Both the novel AJCC classification and the ENETS classification were highly prognostic for survival.

Conclusion: The AJCC TNM classification for pancreatic NETs is prognostic for OS and can be adopted in clinical practice.

Publication types

  • Validation Study

MeSH terms

  • Adolescent
  • Adult
  • Advisory Committees
  • Aged
  • Aged, 80 and over
  • Analysis of Variance
  • Female
  • Gastrinoma / mortality
  • Gastrinoma / pathology
  • Glucagonoma / mortality
  • Glucagonoma / pathology
  • Humans
  • Incidental Findings
  • Insulinoma / mortality
  • Insulinoma / pathology
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Neuroendocrine Tumors / classification
  • Neuroendocrine Tumors / mortality*
  • Neuroendocrine Tumors / pathology*
  • Pancreatic Neoplasms / classification
  • Pancreatic Neoplasms / mortality*
  • Pancreatic Neoplasms / pathology*
  • Predictive Value of Tests
  • Prognosis
  • Proportional Hazards Models
  • Reproducibility of Results
  • Retrospective Studies
  • Risk Factors
  • United States / epidemiology
  • Vipoma / mortality
  • Vipoma / pathology