HPV pseudovirions as DNA delivery vehicles

Ther Deliv. 2011 Apr;2(4):427-30. doi: 10.4155/tde.11.28.

Abstract

"The ability of HPV pseudovirions to efficiently deliver DNA into cells suggests several potential applications in basic biology, including the characterization of virion biology and measurement of protective neutralizing antibody titers in vitro and in vivo, as well as their employment for more direct medical applications".

Keywords: DNA delivery; DNA vaccine; HPV pseudovirions; human papillomavirus; neutralization assay.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Antibodies, Neutralizing / immunology
  • Gene Transfer Techniques*
  • Genetic Vectors / immunology
  • Genetic Vectors / therapeutic use*
  • Humans
  • Papillomaviridae / genetics*
  • Virion / genetics*
  • Virion / immunology

Substances

  • Antibodies, Neutralizing