Physiopathology of Idiopathic Nephrotic Syndrome: Lessons From Glucocorticoids and Epigenetic Perspectives

Pediatr Nephrol. 2012 Aug;27(8):1249-56. doi: 10.1007/s00467-011-1947-1. Epub 2011 Jun 28.

Abstract

Idiopathic nephrotic syndrome (INS) has been studied for decades in attempt to understand the physiopathological mechanisms explaining the disease. It is recognized as a multifactorial disease, with immunological components targeting kidney functions. Many hypotheses have been discussed or tested, including the role of a circulating factor, polymorphisms of genes implicated in lymphocyte maturation and differentiation, and DNA epigenetic modifications. In the present review, the data supporting these different (and probably combinatorial) hypotheses have been reviewed in order to identify and discuss the possible pathways implicated in the physiopathology of INS.

Publication types

  • Review

MeSH terms

  • Child
  • Epigenesis, Genetic
  • Glucocorticoids / therapeutic use*
  • Humans
  • Nephrotic Syndrome* / genetics
  • Nephrotic Syndrome* / immunology
  • Nephrotic Syndrome* / physiopathology

Substances

  • Glucocorticoids