Deciding whether to go with the flow: evaluating the merits of flow reactors for synthesis

Angew Chem Int Ed Engl. 2011 Aug 8;50(33):7502-19. doi: 10.1002/anie.201004637. Epub 2011 Jun 27.

Abstract

The fine chemicals and pharmaceutical industries are transforming how their products are manufactured, where economically favorable, from traditional batchwise processes to continuous flow. This evolution is impacting synthetic chemistry on all scales-from the laboratory to full production. This Review discusses the relative merits of batch and micro flow reactors for performing synthetic chemistry in the laboratory.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bioreactors*
  • Chemistry Techniques, Synthetic / instrumentation*
  • Chemistry Techniques, Synthetic / methods*
  • Drug Industry
  • Laboratories
  • Microfluidic Analytical Techniques*
  • Organic Chemicals / chemical synthesis*
  • Organic Chemicals / chemistry
  • Pharmaceutical Preparations / chemistry*

Substances

  • Organic Chemicals
  • Pharmaceutical Preparations